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Quick Look Metabolism addresses 74 themes that are fundamental to the understanding of metabolism. The book emphasizes the function and underlying principles of metabolic pathways, their cellular and organ distribution, how they are fegulated and coordinated with one another, and the clinical significance of the pathways. Each theme has comprehensive, composite illustrations on one page and concise text on the facing page. The text begins with a brief overview, is followed by thumbnail sketches of key concepts, and ends with a discussion of clinical significance. There are 160 USMLE-format review questions and answers with explanations for self-assessment.
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Table of Contents
- FRONT MATTER
- 1 Cellular Organelles and Their Metabolic Functions
- 2 Biologic Buffers and Acid-Base Equilibrium
- 3 Protein Structure
- 4 Collagen: The Major Connective Tissue Protein
- 5 Plasma Proteins
- 6 Membrane Structure and Transport Properties
- 7 Hemoglobin Structure and Function
- 8 General Properties of Enzymes
- 9 Enzyme Kinetics
- 10 Regulation of Enzyme Activity
- 11 Transduction of Hormonal Signals Across Membranes
- 12 Nutritional Basis of Metabolism: Macronutrients
- 13 Nutritional Basis of Metabolism: Micronutrients
- PART I QUESTIONS
- 14 Thermodynamic Principles of Metabolism
- 15 Oxidative Metabolism
- 16 Mitochondrial Compartments
- 17 Catabolic Functions of the TCA Cycle
- 18 Anabolic Functions of the TCA Cycle
- 19 Electron Transport Chain: Oxidation of NADH and FADH2
- 20 Oxidative Phosphorylation: Mitochondrial ATP Synthesis
- 21 Interconversion of Metabolic Fuels
- PART II QUESTIONS
- 22 Digestion and Absorption of Carbohydrates
- 23 Effects of Insulin on Blood Glucose
- 24 Effects of Glucagon on Blood Glucose
- 25 Glycolysis
- 26 Metabolic Fate of Pyruvate
- 27 Glycogen Metabolism
- 28 Coordinate Regulation of Glycogen Metabolism
- 29 Gluconeogenesis
- 30 Coordinate Regulation of Glycolysis and Gluconeogenesis
- 31 Pentose Phosphate Pathway
- 32 Galactose, Fructose, and Glucuronic Acid Metabolism
- 33 Glycosylation of Proteins
- 34 Proteoglycans
- PART III QUESTIONS
- 35 Lipid Digestion and Absorption
- 36 Structure and Function of Lipoproteins
- 37 Chylomicron Metabolism
- 38 Very-Low-Density, Intermediate-Density, and Low-Density Lipoprotein Metabolism
- 39 High-Density Lipoprotein Metabolism
- 40 Cholesterol and Bile Acid Metabolism
- 41 Steroid Hormone Metabolism
- 42 Fatty Acid Synthesis and Storage
- 43 Fatty Acid Mobilization and Oxidation
- 44 Ketone Metabolism
- 45 Coordinate Regulation of Fatty Acid Metabolism
- 46 Phospholipids
- 47 Sphingolipid and Glycolipid Metabolism
- 48 Essential Fatty Acids and Eicosanoid Metabolism
- PART IV QUESTIONS
- 49 Dietary Protein Requirement and Nitrogen Balance
- 50 Protein Digestion and Amino Acid Absorption
- 51 Interorgan Exchange of Amino Acids
- 52 Removal of Amino Groups and Disposal of Carbon Skeletons
- 53 Detoxification of Ammonia
- 54 Branched-Chain Amino Acid Metabolism and Organic Acidurias
- 55 Hepatic Aromatic Amino Acid Metabolism
- 56 Extrahepatic Metabolism of Tyrosine
- 57 Biogenic Amines Derived from Amino Acids
- 58 Transfer of One-Carbon Units in Metabolism
- 59 Metabolism of Sulfur Amino Acids and Peptides
- 60 Porphyrin and Heme Metabolism
- 61 Nitric Oxide Metabolism
- 62 Purine Nucleotide Synthesis
- 63 Salvaging and Degradation of Purine Nucleotides
- 64 Pyrimidine Nucleotide Metabolism
- PART V QUESTIONS
- 65 Organizing Themes in Metabolism
- 66 Branch Points in Metabolism
- 67 Tissue and Subcellular Specialization
- 68 Liver: The Nutrient Clearing Center
- 69 Glucose Homeostasis During Fasting
- 70 Hepatic Fuel Metabolism in the Well-Fed State
- 71 Hepatic Fuel Metabolism in the Fasting State
- 72 Metabolic Changes in Diabetes Mellitus
- 73 Effect of Ethanol on Metabolism
- 74 Inheritance Patterns of Metabolic Diseases
- PART VI QUESTIONS
